Blar i forfatter "Engesland, André"

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    • Hydrogels of natural origin in wound healing : formulation devolopment 

      Engesland, André (Master thesis; Mastergradsoppgave, 2010-05-20)
      Hydrogels made of chitosan has a well-established place in drug delivery for the skin. Our particular interest were hydrogels for wound healing. Hydrogels from low, medium and high molecular weight were prepared in different concentrations for texture and release characterization incorporating liposomes and chloramphenicol as a model drug. A method for comparing viscosity between gels was established ...

    • In vitro permeation models for healthy and compromised skin: The Phospholipid Vesicle-based Permeation Assay (PVPA) for skin applications 

      Engesland, André (Doctoral thesis; Doktorgradsavhandling, 2015-03-20)
      In vitro models with the ability to estimate drug penetration through healthy and compromised skin may reduce animal testing of drugs and cosmetics to a minimum. The phospholipid vesicle based permeation assay (PVPA) is based on a tight barrier composed of liposomes mimicking cells. It was originally made to mimic the intestinal epithelial barrier and in this project further developed to mimic the ...

    • In vitro skin models as a tool in optimization of drug formulation 

      Flaten, Gøril Eide; Palac, Zora; Engesland, André; Filipović-Grčić, Jelena; Vanić, Željka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-30)
      (Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the ...

    • Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development 

      Palac, Zora; Engesland, André; Flaten, Gøril Eide; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)
      Penetration potential of vesicles destined for trans(dermal) administration remains to be of great interests both in respect to drug therapy and cosmetic treatment. This study investigated the applicability of the phospholipid vesicle-based permeation assay (PVPA) as a novel in vitro skin barrier model for screening purposes in preformulation studies. Various classes of liposomes containing hydrophilic ...

    • Phospholipid Vesicle-Based Permeation Assay and EpiSkin in Assessment of Drug Therapies Destined for Skin Administration 

      Engesland, André; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)